Smart imaging nanosensors for detecting and discriminating thrombosis - the silent killer

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1. Please give a summary of your research.

Did you know that cardiovascular disease such as thrombosis (blood clot) is the world's biggest killer? The clots can block the blood flow to the legs, the lung, the heart, and the brain, which can cause life-threatening events such as pulmonary embolism, heart attack, and stroke. Early detection of these blood clots is very important to enable early treatment, which prevents complications and death. There are a couple of imaging techniques that can detect the clots. However, they are not able to provide information on the age of the clots or the progression of the disease which is very critical for a clinician to decide a suitable treatment.


I'm working on solving this problem. My group has developed a very tiny particle (in the nanoscale size) that can not only detect the clots but also sense and report information on the progression or the age of the clots. I call this "a smart nanosensor for detecting and discriminating thrombosis - the silent killer". My project will develop these tiny agents for the reliable and safe diagnosis of thrombotic events using magnetic resonance imaging (MRI), a widely-available imaging system in clinical settings. The central aim of the project is to develop novel imaging agents with improved functionality and efficacy based on well-known non- or low toxic materials and materials approved by FDA, which enables easy translation to clinical use.


These nanosensors can be injected into the body, trace and bind to the blood clots and then can be tracked by widely used MRI machines. Especially they can switch between different imaging signals by sensing the age of the clots. By doing so, they can smartly provide information on both the location of the blood clots and the current stage or the progression of the disease.

2. Please include any additional details you would like to share

Significance of the project

This research tackles a vital clinical problem, how to image and distinguish between fresh thrombi and aged thrombi so as to prescribe an appropriate treatment. Current clinical technologies are unable to achieve this. Pre-clinical attempts are inadequate. Thrombolytic drugs are used to dissolve blood clots and are commonly used in patients with myocardial infarction, thrombotic stroke, and pulmonary embolism. There are three major classes of thrombolytic or fibrinolytic drugs: tissue plasminogen activator (tPA), streptokinase (SK), and urokinase (UK), with tPA being the most commonly used. Hemorrhage or bleeding is the most common side effect of these drugs and it can be life-threatening. It is well-known that the success rate of fibrinolytic therapy is higher in fresh thrombosis than in old thrombosis. Therefore it is critical to not only localize the thrombus but also determine its age to decide accurate treatment regime. Non-invasive differentiation between old and fresh thrombi would be of clinical importance to estimate the risk for embolization and the necessity of anticoagulation. The working principle demonstrated in this study can be applied to many other diseases such as cancer.


About Dr Hang Ta:

Dr. Hang Ta holds joint appointments at Australian Institute for Bioengineering and Nanotechnology and School of Pharmacy, the University of Queensland. She leads a group of 8 students working on nanomaterials for diagnosis and treatment of cardiovascular diseases. She is a pioneering bio-nanomaterials researcher developing innovative nanomaterials and magnetic resonance imaging (MRI) nanosensors for molecular imaging and drug delivery for cardiovascular diseases. She has been awarded a number of research prizes, grants and prestigious fellowships for her innovative ideas and projects. She is committed to develop strategic nanotechnology solutions to improve people's health.

Comments

52
Manh Tran
about 2 years ago

A fantastic research! Best of luck !

rc rc
about 2 years ago

Best of luck Hang - a wonderful research project!

Ohan Mazigi
about 2 years ago

Pioneering work! Good luck Hang!

Khoa Nguyen
about 2 years ago

Great work! Good luck Hang!

LI LI
about 2 years ago

Great job, Hang! Good luck

hai Cao Minh
about 2 years ago

Congratulations my teacher!

Gordon Xu
about 2 years ago

Good project!

Amy Leslie
about 2 years ago

Best of luck on your project!

Roger Wu
about 2 years ago

Brilliant project!

Dr Peter Isdale AM
about 2 years ago

I know how committed you are, Hang, and how hard you work. That is worthy of support in anyone's terms. It's a great project, and will have real impact. Good Luck.

AI Nguyen
about 2 years ago

Great project! We need it

Phi Le
about 2 years ago

Good luck Hang oi.

Vinh Dao
about 2 years ago

Great work!

Yakob Haron
about 2 years ago

Good project. All the best.

Van Thi Hoang Tran
about 2 years ago

Great project chi!!! All the best to you :)

Tâm Nguyễn
about 2 years ago

Good luck em nhé

Liyu Liyu
about 2 years ago

very promising project which could benefit cardio disease patients a lot

THI KIEU ANH DINH
about 2 years ago

Interested in your research

maianh thibui
about 2 years ago

love your work that would be a great contribution to medical industry

Tuan Nguyen
about 2 years ago

Brilliant work and all the best to you !

Thong Le
about 2 years ago

An amazing research project. Very meaningful and will definitely make a huge contribution to our medical industry. All the best my friend! I am sure your dream will come true.

Thirstybear Nguoibinhthuong
about 2 years ago

Good work!!!!!!!!!!!!!!!!!

Vinh Phuc Ta
about 2 years ago

Go win!!!

Duc Hoang Nguyen
about 2 years ago

Excellent study and good lucks!

Hui Jean Lim
about 2 years ago

All the best!

Henric Cao
about 2 years ago

Excellent project.
If possible, should you change "I" into "We" in your video introduction. It's rather better!
Good luck!

Anh Doan
about 2 years ago

Good luck Hang nhe

Nam Lý
about 2 years ago

Great idea, great job Hang! All the best!

Quang Dzung
about 2 years ago

Great work Hang!

Lien Pele Nguyen
about 2 years ago

Exceptional research. You and your team have done a great work. Looking forward to knowing the study practically applied to save people life.

Minh Huong Pham
about 2 years ago

Great work! A useful research for people health. Good luck for you and your team. All the best wishes for you

Anh Kim Le
about 2 years ago

Brilliant work Hang, good luck!!!!

Tong Phuc
about 2 years ago

Great project! Good luck to you!

Tam Oro
about 2 years ago

Excellent work! Hope it successful!

Văn Doanh Tạ
about 2 years ago

Great project, good luck!!!

Như Thảo Phan
about 2 years ago

Good luck to you !

Linh Ta
about 2 years ago

Good work-well done

Loc Ta
about 2 years ago

Great Job

Minh Thu Ma
about 2 years ago

Great job .

THUY NGOC HONG NGUYEN
about 2 years ago

Good luck nha Hằng?

Lâm Lê Hồng
about 2 years ago

Good luck winning !!!

Quynh Thu Ngo
about 2 years ago

Great job !

Doan Nguyen
about 2 years ago

Brilliant ! Good luck Hang

Bao Vo
about 2 years ago

Great research by a brilliant scientist :-) Good luck Hang.

Hai Hoi
about 2 years ago

Great work!
Good luck @Hang.

Barry Le Cornu
about 2 years ago

You should be very proud of your continued and vital work, Hang. Well done!

Ta van Khoa
about 2 years ago

??❤️❤️Excellent

Phi Vuong
about 2 years ago

That’s great! So proud of you and your brother!

Quynh Duc
about 2 years ago

Great!

Hồng Hồng
about 2 years ago

Best of luck on your project.

Tan Tran
about 2 years ago

Good job. All the best!

Dang Hy Cuong
about 2 years ago

Good Luck !