Investigating the Hepatitis C epidemic in Australian prisons

$36,000

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1. Please give a summary of your research.

Prisons are enclosed facilities built to confine law offenders and separate them from the rest of the community. While these structures have been successful in increasing public safety, sub-standard living conditions and high-risk behavior tend to compromise prisoner health by putting them at an increased risk of disease infection, particularly blood-borne virus infection. 


Hepatitis C virus (HCV) is the most common blood-borne virus circulating in prisons due to a high population of incarcerated people who inject drugs (PWID) and the prevalence of unsafe injecting practices. Currently, the implementation of HCV prevention programs in Australia remain inadequate. While the use of highly effective and short-term direct acting antivirals to cure HCV has emerged, treatment implementation and delivery in prisons remain neglected. Regardless of how high treatment uptake is in the community, it is unlikely to achieve HCV elimination if key populations, such as prisoners, are left behind.


My research explores the dynamics of HCV transmission and evaluates strategies on mitigating ongoing transmission in the Australian prison setting, particularly in New South Wales (NSW). I use an integrated approach of epidemiology, bioinformatics, and computational modelling. Using a well-defined longitudinal cohort of prisoners with 6-monthly blood samples and self-reported injecting behaviour, surveillance was performed by calculating the HCV incidence in this population. Associated risk factors were also identified using statistical analysis. Transmission events were then reconstructed and transmission clusters were identified from this cohort. This was achieved by applying phylogenetic analysis on the E1-hypervariable region of the collected sequences and mapping closely-related sequences with injecting risk behaviour, and geographic and temporal information. Finally, a computational agent-based model was developed to simulate the future of the HCV epidemic in NSW prisons. Ultimately, this model will be used to assess the impact of treatment and prevention strategies (e.g. NSP) in eliminating HCV in this setting.


2. Please include any additional details you would like to share

The researcher has won the following for this research:

  1. Westmead Millenium Institute for Medical Research - Young Achiever Award in Hepatitis 2013
  2. UNSW International Research Candidate Scholarship 2013-2016


Portions of this research have also been published in:

  1. A prospective study of hepatitis C incidence in Australian prisoners Addiction, 2014; Oct;109(10):1695-706.
  2. Transmission of hepatitis C virus among prisoners, Australia, 2005-2012 Emerging Infectious Diseases, 2015; May;21(5):765-74.
  3. Ongoing incident hepatitis C virus infection among people with a history of injecting drug use in an Australian prison setting, 2005-2014: The HITS-p study Journal of Viral Hepatitis, 2017; April; 10: 10.1111




Comments

17
Carmela Magallona
about 2 years ago

This is helpful, great work! ?

Gina Buenvenida
about 2 years ago

Excellent work! You deserved to get the funding! Good Luck Neil.....

lol lol
about 2 years ago

Good luck best brother

Masabre25 Masabre25
about 2 years ago

You are deserving for the win. Go go go Dr. Neil!!!

Marj Pabilonia
about 2 years ago

Great work :) Good luck!

Alf Juico
about 2 years ago

I hope your research furthers the understanding, cure and eradication of this viral desease.

Earle Buenvenida
about 2 years ago

Good luck

Joyce Vill
about 2 years ago

Good info good research thank you good luck

Nolan Bretana
about 2 years ago

Very naisu

MJun Ladan
about 2 years ago

Good luck

Stuart Loveday
about 2 years ago

Yours is exceptionally important work, Neil. Thank you. All the best for success in the judging for this award. With kind regards. Stuart Loveday, CEO Hepatitis NSW, Sydney Australia.

Joshua Cyril Arbolente
about 2 years ago

Done voting. Goodluck!

Bing Jardeniano
about 2 years ago

done voting

Raymund Perez
about 2 years ago

Good luck, Neil!

Elizabeth Pedersen
about 2 years ago

Well, good luck for the project.

Bing-Ru WU
about 2 years ago

good work.Neil

Michael John
11 months ago

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Image1501205359?1501205359
Round: External Judging
Category: People's Choice Award

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