3D spheroids: Using microfluidics to cure lung diseases

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Fernando Jativa
over 2 years ago

The Therapeutic Technologies Research Initiative (TTRI) is focused on new applications of mechanopharmacology and organ-on-a-chip technology to transform drug-screening processes.

The Initiative has selected three Research Themes as initial areas of focus: drug evaluation, mechanopharmacology and disease remodeling.

You can find more information at: http://research.unimelb.edu.au/hallmark-initiatives/therapeutic-technologies-research-initiative

Thank you for your support!

Fernando Jativa
over 2 years ago

Here is the video script:
Hi! My name is Fernando Jativa and welcome to The University of Melbourne. Today I want to take you in a visit to the lung health research centre and the Mechanopharmacology Lab.

Is in here were I do my PhD and I apply my engineering background for the study of the lung and lung diseases. Our bodies are in almost constant motion, and each of our cells participate in this dynamic environment. And the lung is no exception.

Lung diseases are some of the most common medical conditions in the world. At least one in every 4 Australians have a lung disease, and
approximately 14% of all deaths each year are a result of asthma, lung cancer, COPD, pneumonia and other lung diseases (1)

Therefore we urgently need new ways to study and treat them. However, studying living cells in the lab can be quite challenging. If we want to make cells happy outside our bodies, we must replicate the dynamic environment and their 3D structure.

Traditional lab techniques use a single layer of cells in plastic. In our research, we use 3D aggregates of more than 50k cells interacting together in a single structure. We call them spheroids, and they give us very interesting insights on how diseases develop. Furthermore we can engineer microfluidic channels to determine their mechanical properties. Spheroid and single cell deformation allow us determine relevant properties as stiffness,compresibility and viscosity.

Our results show that in spheroids from lung disease patients, as in fibrosis, unhealthy cells in spheroids undergo cell remodeling, stiffness increase, and changes in gene expression

Hope you enjoyed this quick video, this is what we are doing in the university of Melbourne, see you next time!

Riley Soares
over 2 years ago

This is incredible, Fernando!

Michael de Stoop
over 2 years ago

Fernando, you are in my prayers in the hope that your excellent research may lead to a breakthrough that heals many people.

Andres Jativa
over 2 years ago

Muy interesante tu investigación

Inty Gronneberg
over 2 years ago

Amazing video from an amazing researcher

Norma Flores
over 2 years ago

Muy orgullosa de su capacidad cientifica

Sabine Milliau
over 2 years ago


Leno Avila Vélez
over 2 years ago

Interesante investigación

Markus G-point
over 2 years ago

U are the man dude!!

Mijail Jativa
over 2 years ago

Bien. Sigue adelante

ryan mateo
over 2 years ago

awesome Fer!

Carlota Bonifaz
over 2 years ago

Interesante tu trabajo, sigue adelante

Sunshine Alimagno
over 2 years ago

Praying that the success of this study may be fruitful, far-reaching and may glorify the Creator. Good luck!

Chandra Yerrappa
over 2 years ago

Great video! Good luck with the competition and your research.

Nancy de Sánchez
over 2 years ago

Dios le bendiga

Ramiro Vallejo
over 2 years ago



Fernando is in the third year of his PhD in Biomechanics. His multidisciplinary project, on how lung disease affects the mechanical properties of lung tissues, is co-supervised by Professors Alasta...

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