Living bioelectronics: Creating functional interfaces between devices and tissues

Play Video

$37,050

Prizes

5,495

Views

1. Summary

The ultimate objective of this research is to create a paradigm shift in biomedical electrode design. Rather than relying on unwieldy metal electrodes and direct charge injection, tissue engineered bioelectronics use cells embedded within devices to provide a natural mode of physiological tissue activation. These new designs provide communication, such as recording or stimulation, through formation of functional synapses between devices and cells. This revolutionary approach provides a safer mechanism for neural cell stimulation, which is more compatible with neural cell survival and regeneration. It will also support development of more complex and elegant devices to restore sensory and motor functions.

2. Description

To achieve optimal performance from bionic devices, an intimate connection between “hard” device and “soft” excitable tissue is required. Existing bionic implants use metal electrodes, which have a restircted ability to transfer electricity to biological tissues and poor integration with cells. This limits their use in next-generation, high resolution devices, such as the bionic eye and brain-machine interfaces. Alternate materials have been explored as coatings to improve the performance of metal electrodes, but scar tissue formation remains a problem. This research project has yielded a new approach of incorporating neural cells within a bioactive conductive hydrogel (CH) electrode to promote functional, physiological junctions between device and tissue.

To develop these "living bioelectronics" a hydrogel carrier has been engineered to provide appropriate cues that support survival and differentiation of cells into neural networks, while also enabling transfer of electricity and recording of cellular activity. The living electrode construct has been developed and it has been shown that the electrical properties of these new cell loaded materials are significantly better than traditional metals, such as platinum, indicating that this construct can be used to drive devices at lower power. It is proposed that this structure can address the need for such intimate communication between device and cells and can be safely used in micro-scale implantable devices. Neural cells and supporting glia have been encapsulated within the electrode materials and shown to both differentiate and be capable of forming active neural networks that have instrinic electroactivity and respond to electrical stimulation.

Ultimately, it is expected that functional cells that are embedded in bionic devces will effectively support an integrated interface with indistinct borders between synthetic devices and the surrounding tissue. This type of construct can be used to create not only direct connections to neural tissues, but also neuro-muscular junctions (NMJ) to record cell activity and drive peripheral prosthetics or rehabilitating limbs (via functional electrical stimulation, FES). Living bioelectronics have application across a wide range of medical implants, including robotic peripheral limb prostheses, cochlear implants, deep brain stimulators, cardiac pacemakers and other medical electrodes.

 

3. Additional Details

Papers we have published on this topic:

  1. Aregueta-Robles UA, Lim KS, Martens PJ, Lovell NH, Poole-Warren LA, Green RA. “Producing 3D Neuronal Networks in Hydrogels for Living Bionic Device Interfaces” 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Milan, Italy, 4pp, 2015.
  2. Green RA, Lim KS, Henderson WC, Hassarati RT, Martens PJ, Poole-Warren LA, Lovell NH. “Living electrodes: Tissue engineering the neural interface”, Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Osaka, Japan, 4pp, 2013.
  3. Patton AJ, Amella AD, Martens PJ, Lovell NH, Poole-Warren LA, Green RA (invited speaker). “Freestanding, soft bioelectronics” Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering, Montpellier, France, 4pp, Accepted for publication 2015
  4. Aregueta-Robles UA, Woolley AJ, Poole-Warren LA, Lovell NH, Green RA, “Organic electrode coatings for next-generation neural interfaces” Frontiers in Neuroengineering, 7(15), 1-18, 2014. 
  5. Hassarati RT, Dueck WF, Tasche C, Carter P, Poole-Warren LA, Green RA, “Improving cochlear implant properties through conductive hydrogel coatings,” IEEE Transactions on Neural Systems and Rehabilitation Engineering, 22(2) 411-418, 2014.
  6. Cheong GLM, Lim KS, Jakubowicz A, Martens PJ, Poole-Warren LA, Green RA. “Conductive hydrogels with tailored bioactivity for implantable electrode coatings”, Acta Biomaterialia,10(3), 1216-1226, 2014.

Links to more information on my research:

http://www.news-medical.net/news/20130114/Bionic-devices-an-interview-with-Dr-Rylie-Green.aspx

http://freshscience.org.au/2010/electric-plastics-better-bionic-eyes-and-ears

https://www.engineering.unsw.edu.au/biomedical-engineering/staff/rylie-green

http://ignitionlabs.com.au/unsw-researchers-given-easy-access-to-nsw-medical-device-commercialisation-training-program

 

 

Comments

5
Principe Principe
11 months ago

Longchamp
Longchamp Bag
Longchamp Bags
Longchamp Sale
Longchamp Outlet
Longchamp Backpack
Longchamp Purses
Longchamp Bag Sale
Longchamp Sale Handbags
Longchamp Bags Outlet
Michael Kors Outlet
Michael Kors Sale
Michael Kors Outlet Online
Michael Kors Outlet Online Sale
Michael Kors
Michael Kors Handbags
Michael Kors Bags
Michael Kors Purses
Nike Free Run
Nike Free 5.0
Nike Store
Nike Free
Nike Free 4.0
Nike Free 3.0
Air Max 1 Ultra Moire
NIKE HYPERADAPT 1.0
Kobe 12
Kobe AD
Kobe bryant Shoes
Kobe Shoes
Kobe 11 Shoes
Kobe 11
Kobe 11 Elite
Kobe Shoes
Cheap Jordans for Sale
Cheap Jordans
Cheap Jordan Shoes
Jordans for Sale
Jordans Shoes 2018
New Jordans 2018
Jordan Shoes
Jordan Shoes For Sale
Red Bottom Shoes For Women
Red Bottom Shoes
Red Sole Shoes Christian Louboutin
Red Bottoms Shoes On Sale
Red Bottom Shoes Christian Louboutin
Christian Louboutin
Christian Louboutin Sale
Christian Louboutin Shoes on Sale
Christian Louboutin Shoes
Christian Louboutin Outlet
Nike VaporMax
Nike Air Max
Nike VaporMax Flyknit
Nike Air Max 2017
Nike Air Max 2018
Nike Air Max 2016
Air Max 95
Air Max 87
New Nike Shoes 2017
Nike Air Max Tavas
Special Field Air Force 1s
Nike Air Max Tailwind 8
Kobe Shoes
Kobe AD
Kobe AD Shoes
Nike Kobe AD
Kobe A.D.
Kobe A.D. Shoes
Eqt Adidas
Adidas Eqt
Adidas Eqt Support
Adidas Eqt Adv
Adidas Eqt Support Adv
Adidas Eqt Support 93/17
Harden Shoes
James Harden Shoes
Harden Vol 1
Harden Vol 2
Adidas Crazylight Boost
Harden Vol 1 Shoes
adidas Crazy Explosive 2017
adidas Dame 4
KD Shoes
KD 9
KD 9 Elite
KD 9 Shoes
Nike Kyrie 3
Kevin Durant Shoes
Kyrie 4 Shoes
Nike Kyrie S1 Hybrid
Off-White x Nike React Hyperdunk 2017
Off-White x Kyrie 4
Kyrie 4
Kyrie 2
kyrie irving shoes
Kyrie Shoes
Kyrie 3
Kyrie 3 Shoes
Lebron 14
Lebron Shoes
Lebron 14 Shoes
Lebron 14 Low
LeBron Ambassador 9
LeBron Soldier 10
NBA Store
Basketball Shoes
Curry Shoes
NBA Stars Shoes
Lebron Shose
NBA Shoes
Curry 3
Curry 2
Nike Flyknit
Nike Flyknit Racer
Nike Flyknit Lunar 3
Nike Flyknit 4.0
Nike Outlet
Nike Store
Nike Factory Store
Nike Factory
Jordan Shoes
Cheap Jordans
Nike Shoes 2017
Nike Air Max
New Yeezy Boost
Cheap Yeezys
Yeezy 700
Yeezy Boost 500
Adidas Yeezy Powerphase
Kids Yeezy Shoes
Adidas Yeezy Boost 350
Adidas Yeezy Boost 350 V2
Yeezy Boost 350
Yeezy Boost 350 V2
Yeezy Wave Runner 700
Yeezy Desert Rat 500
Yeezy Powerphase Calabasas
Yeezy Boost 350 V2 Kids
Nmd R2
Nmd R1
Addidas Nmd
Nmd Xr1
Human Race Nmd
Yeezy 500
Adidas Shoes 2018
Cheap Adidas Shoes
Adidas NMD R1
Adidas NMD R2
Harden Vol. 2
Harden Vol. 1
Adidas NMD Human Race
Adidas Yeezy Boost
Adidas Ultra Boost 4.0
Adidas Ultra Boost 3.0
NBA Jerseys
Cheap NBA Jerseys
www.newyeezyboost.us.com
www.cheapnbajerseys2017.com
Cheap Ray Bans
Ray Ban Sale
Ray Ban Sunglasses Sale
Ray Bans On Sale
Cheap Ray Ban Sunglasses Sale
Ray Ban Wholesale
Ray Ban Sunglasses Outlet
Ray Ban Sunglasses Cheap
Coach Outlet Online
Coach Outlet
Coach Bags
Coach Purses
Coach Factory
Coach Factory Outlet
Coach Outlet Store Online
Coach Factory Store
Coach Bags Outlet
Coach Bags On Sale
Coach Purses On Sale
Coach Purses Outlet Online

zian rizky
5 months ago

4 Toko grosir tas import di batam Penyedia Tas Branded di Batam . Toko tas branded bertebaran di setiap pusat perbelanjaan di Batam, Kepulauan Riau. Mencari Distributor Tas grosir handbag murah Batam Untuk Bisnis - Tas Batam Termurah

zian rizky
5 months ago

Grosir Tas Bandung Online - Kota Bandung selain terkenal dengan Factory Outlet (FO) yang menawarkan beragam macam pakaian, juga salah satu pusat perbelanjaan grosir tas murah. Tas Bandung atau tas yang di produksi di kota bandung ini banyak diburu oleh wisatawan lokal maupun mancanegara grosir tas ransel anak murah.